TN-1 is a chemical developed by Bane to try and kick his addiction to the steroidal compound venom.
The affect of the drug increases muscle capacity permanently, but as a side affect reduces the memory and intelligence of the user.
Bane tries to improve the formula to remove the side effect, testing it on several members of his crew, however is unable to improve it before being forced to take the serum himself when trying to kill Batman at Blackgate. This results in Bane, forgetting Batman's identity and turning into a giant, muscular brute.
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